【Detail】
Chemical Description
◆ Product name: Copovidone, PVP VA 64
◆ Brand name: BOVIDONE® VA 64
◆ CAS NO.: 25086-89-9
◆ INCI Name: PVP/VA Copolymer
◆ CEP Reg. No: 2019-199
DMF Reg. No: 33953
Physical and Chemical properties
-- A white to yellowish white, hygroscopic powder, lower hygroscopicity than povidone;
-- Freely soluble in water and a variety of organic solvents;
-- with more compatible excellent film forming agent;
Typical Properties
Specification
|
No. |
Specification |
Ph Eur |
|
1 |
Viscosity, as K-value |
27.0-33.0 |
|
2 |
Loss on drying |
≤5.0% |
|
3 |
Impurity A (2-pyrrolidone) |
≤0.5% |
|
4 |
Peroxides |
≤400ppm |
|
5 |
Heavy metals |
≤10ppm |
|
6 |
1-Vinylpyrrolidin-2-one |
≤10ppm |
|
7 |
Vinyl Acetate |
≤10ppm |
|
8 |
Element Impurity |
Fulfil ICH Q3D |
Applications
◆ Used as an excellent adhesive for tablets and granules, it can be used in direct tablet pressing and wet or dry granulation.
◆ Used as an excellent film forming agent, which is used in the coating solution of tablets, granules, pellets and the core of sugar-coated tablets, as well as the spray of local medication, the film coating and spray which made by Bovidone VA 64 are flexible, with low water absorption, high plasticity and low viscosity.
◆ Used as solubilizer to increase the solubility and bioavailability of drug preparations.
Packing and Storage
◆ Packed in 25kg fiber or plastic drum, inner lined with double medicinal polyethylene film bag.
◆ Stored in dry place at room temperature.
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